Didier Merlin Selected Research

MSH (11-13)

5/2016	Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of the anti-inflammatory PepT1-mediated tripeptide KPV in a murine model.
3/2010	Drug-loaded nanoparticles targeted to the colon with polysaccharide hydrogel reduce colitis in a mouse model.

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Didier Merlin Research Topics

Disease

54	Inflammation (Inflammations) 03/2021 - 09/2002
51	Colitis 03/2021 - 07/2005
27	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2022 - 09/2003
18	Ulcerative Colitis 06/2022 - 04/2006
12	Neoplasms (Cancer) 12/2019 - 12/2008
10	Colonic Neoplasms (Colon Cancer) 04/2022 - 01/2010
6	Colitis-Associated Neoplasms 01/2021 - 01/2010
5	Infections 06/2022 - 02/2009
5	Carcinogenesis 01/2019 - 03/2007
4	Body Weight (Weight, Body) 05/2014 - 04/2004
3	Colorectal Neoplasms (Colorectal Cancer) 07/2020 - 01/2012
3	Carcinoma (Carcinomatosis) 01/2012 - 04/2006
2	Hemochromatosis (Bronze Diabetes) 05/2021 - 01/2019
2	Intestinal Diseases (Diseases, Intestinal) 07/2020 - 01/2007
2	Wounds and Injuries (Trauma) 01/2020 - 01/2018
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 03/2017 - 12/2008
2	Arthritis (Polyarthritis) 03/2017 - 01/2017
1	Iron Overload 05/2021
1	Anemia 01/2021
1	Bacterial Infections (Bacterial Infection) 11/2020

Drug/Important Bio-Agent (IBA)

25	Dextrans (Dextran)FDA Link 07/2020 - 07/2005
22	CytokinesIBA 01/2021 - 09/2003
22	sodium sulfate (sodium bisulfate)FDA LinkGeneric 07/2020 - 07/2005
21	Pharmaceutical PreparationsIBA 06/2022 - 03/2010
18	Proteins (Proteins, Gene)FDA Link 05/2021 - 09/2004
12	Small Interfering RNA (siRNA)IBA 05/2021 - 11/2010
8	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2021 - 04/2006
8	Messenger RNA (mRNA)IBA 01/2012 - 10/2006
7	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2015
7	HydrogelsIBA 01/2018 - 03/2010
7	Peroxidase (Myeloperoxidase)IBA 07/2014 - 12/2002
6	Peptides (Polypeptides)IBA 01/2021 - 05/2002
6	Interleukin-6 (Interleukin 6)IBA 11/2020 - 09/2003
6	Glycoproteins (Glycoprotein)IBA 01/2018 - 07/2005
6	Matrix Metalloproteinases (MMPs)IBA 10/2011 - 12/2005
5	Interleukin-10 (Interleukin 10)IBA 03/2021 - 04/2006
5	LipidsIBA 07/2020 - 01/2016
5	MicroRNAs (MicroRNA)IBA 01/2019 - 01/2010
5	NF-kappa B (NF-kB)IBA 05/2011 - 09/2003
5	Adenosine (Adenocard)FDA LinkGeneric 06/2010 - 09/2002
4	Lipid NanoparticlesIBA 06/2022 - 07/2020
4	Therapeutic UsesIBA 07/2020 - 10/2013
4	ChitosanIBA 01/2018 - 07/2014
4	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 01/2018 - 04/2015
4	Sulfonic AcidsIBA 10/2011 - 09/2008
4	Proline (L-Proline)FDA Link 08/2011 - 10/2008
4	Alanine (L-Alanine)FDA Link 08/2011 - 10/2008
4	Phosphotransferases (Kinase)IBA 08/2011 - 10/2008
4	ProhibitinsIBA 05/2011 - 01/2007
4	ChloridesIBA 01/2009 - 11/2004
3	IronIBA 05/2021 - 01/2019
3	Metalloproteases (Metalloproteinases)IBA 03/2021 - 12/2005
3	Dextran SulfateIBA 10/2020 - 06/2009
3	Matrix Metalloproteinase 9 (Gelatinase B)IBA 01/2020 - 01/2010
3	Doxorubicin (Adriamycin)FDA LinkGeneric 12/2019 - 10/2016
3	Anti-Bacterial Agents (Antibiotics)IBA 01/2019 - 10/2011
3	SodiumIBA 01/2018 - 10/2012
3	CurcuminIBA 08/2017 - 10/2015
3	CamptothecinIBA 08/2017 - 04/2015
3	Hyaluronic Acid (Hyaluronan)IBA 01/2017 - 11/2015
3	LeptinIBA 12/2008 - 04/2004
3	Fibronectins (Fibronectin)IBA 11/2007 - 09/2004
2	Folic Acid (Vitamin M)FDA LinkGeneric 04/2022 - 10/2016
2	HepcidinsIBA 05/2021 - 01/2021
2	Dietary IronIBA 05/2021 - 01/2021
2	LipopolysaccharidesIBA 01/2021 - 01/2017
2	Hormones (Hormone)IBA 01/2021 - 04/2004
2	InterleukinsIBA 11/2020 - 04/2006
2	Interleukin-22 (IL-22)IBA 11/2020 - 10/2018
2	shogaolIBA 10/2020 - 01/2018
2	Nanoparticle Drug Delivery SystemIBA 12/2019 - 12/2016
2	Immunologic Factors (Immunomodulators)IBA 01/2019 - 03/2012
2	ChemokinesIBA 01/2019 - 08/2012
2	AlginatesIBA 01/2018 - 07/2014
2	Glucose (Dextrose)FDA LinkGeneric 01/2018 - 01/2012
2	Mannose (D-Mannose)IBA 01/2018 - 03/2017
2	FlagellinIBA 01/2017 - 11/2004
2	MSH (11-13)IBA 05/2016 - 03/2010
2	Biological ProductsIBA 10/2015 - 04/2004
2	Polysaccharides (Glycans)IBA 09/2014 - 03/2010
2	villinIBA 05/2014 - 10/2011
2	Membrane Transport Proteins (Biological Pump)IBA 03/2012 - 12/2002
2	Transcription Factors (Transcription Factor)IBA 10/2011 - 02/2007
2	sym-trinitrobenzeneIBA 10/2011 - 09/2008
2	AntioxidantsIBA 05/2011 - 07/2009
2	Matrix Metalloproteinase 2 (Gelatinase A)IBA 02/2009 - 09/2006
2	Protein Isoforms (Isoforms)IBA 03/2007 - 07/2006
2	GelatinasesIBA 09/2006 - 12/2005
2	Interferon-gamma (Interferon, gamma)IBA 07/2006 - 04/2006
2	Acetylmuramyl-Alanyl-IsoglutamineIBA 06/2006 - 04/2006
2	Interleukin-8 (Interleukin 8)IBA 04/2006 - 11/2004
2	N-Formylmethionine Leucyl-PhenylalanineIBA 04/2006 - 12/2002
1	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 04/2022
1	Peptide Transporter 1IBA 01/2021
1	Alkaline PhosphataseIBA 01/2021
1	Antimicrobial PeptidesIBA 11/2020

Therapy/Procedure

24	Therapeutics 07/2020 - 06/2009
12	Oral Administration 04/2022 - 01/2008
2	Combination Drug Therapy (Combination Chemotherapy) 11/2015 - 10/2015
1	Fecal Microbiota Transplantation 06/2022